WHY DO WE AGE?
We age because the core systems that keep our cells stable, energised, and able to repair themselves gradually begin to decline.
Over time, DNA damage accumulates, mitochondria weaken, inflammation rises, and communication between cells breaks down.
Scientists have identified twelve key biological processes, known as the Hallmarks of Ageing, that drive this cellular decline.
WHAT ARE THE HALLMARKS OF AGEING?
The Hallmarks of Ageing are the twelve key biological processes that cause our cells to lose function over time.
When these systems weaken, the body’s ability to renew and repair itself declines, leading to the visible and hidden signs of ageing.
By supporting these cellular mechanisms, we can help slow, and even reverse, the aging process at its root.
The 12 Hallmarks of Ageing are:
THE 12 HALLMARKS OF AGING
Genomic Instability
Genomic Instability
DNA damage accumulates daily from oxidative stress and accelerates aging.
Nucleo Greens Ingredients
Vitamin C, Vitamin E, Zinc, Hydroxytyrosol, Polyphenol-Rich Grape Extract, Bio Aronia, Bio Rose Hip Extract, Broccoli Extract, Resveratrol
These nutrients deliver powerful antioxidant defense and essential cofactor support for DNA repair enzymes
Telomere Attrition
Telomere Attrition
Telomeres shorten with each cell division. When they become too short, cells stop dividing and enter senescence, accelerating tissue aging.
Nucleo Greens Ingredients
Resveratrol, Quercetin, Hydroxytyrosol, Broccoli Extract, Spermidine, Siberian Ginseng, Bio Spirulina
These nutrients help activate key longevity pathways, including sirtuins, AMPK, and telomerase activity, supporting telomere stability and healthy cellular renewal.
Epigenetic Alterations
Epigenetic Alterations
The expression pattern of epigenetic markers changes with age, causing cellular dysfunction.
Nucleo Greens Ingredients
Broccoli Extract (Sulforaphane), Resveratrol, Quercetin, Spermidine, Vitamin B9 (5-MTHF), Vitamin B12, Inositol (B8)
These nutrients help preserve optimal gene regulation, maintain proper methylation balance, and promote youthful cellular expression patterns.
Loss of Proteostasis
Loss of Proteostasis
Damaged and misfolded proteins build up inside cells, causes damage to the cell.
Nucleo Greens Ingredients
Spermidine, Resveratrol, Quercetin, R-Alpha Lipoic Acid, Bio Spirulina, Mursala Tea Extract
These nutrients help enhance autophagy, reduce protein aggregation, and support the cell's natural protein repair systems for effective cellular maintenance.
Deregulated Nutrient Sensing
Deregulated Nutrient Sensing
Cellular nutrient and energy sensors (like mTOR, AMPK, and insulin signaling) become dysregulated. This leads to accelerated cellular aging.
Nucleo Greens Ingredients
Resveratrol, Quercetin, Siberian Ginseng, R-Alpha Lipoic Acid, Inositol (B8), Spermidine, CoQ10These compounds help activate key longevity pathways such as AMPK and sirtuins, supporting optimal metabolism, efficient energy use, and metabolic health.
Mitochondrial Dysfunction
Mitochondrial Dysfunction
Mitochondria, the cell's energy factories lose efficiency and produce more free radicals.This results in faster cellular deterioration.
Nucleo Greens Ingredients
CoQ10, R-Alpha Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Bio Spirulina, Bio Spinach, Hydroxytyrosol, Resveratrol
These nutrients help enhance mitochondrial energy output, optimize oxygen metabolism, and protect cells from oxidative damage
Cellular Senescence
Cellular Senescence
Aged or damaged cells stop dividing but release inflammatory molecules that damage surrounding healthy cells.
Nucleo Greens Ingredients
Quercetin, Resveratrol, Spermidine, Polyphenol-Rich Grape Extract, Hydroxytyrosol, Bio Aronia Extract
These compounds act as natural senolytics, helping to clear senescent cells, reduce inflammation, and restore healthy cellular function.
Stem Cell Exhaustion
Stem Cell Exhaustion
Stem cells lose their regenerative capacity.
Nucleo Greens Ingredients
Spermidine, Siberian Ginseng, Bio Spirulina, Hydroxytyrosol, Resveratrol, Vitamin D3, Zinc
These nutrients help support stem cell renewal, enhance tissue repair, and promote long-term cellular resilience.
Altered Intercellular Communication
Altered Intercellular Communication
Cells and organs stop communicating properly. This causes inflammation.
Nucleo Greens Ingredients
Resveratrol, Quercetin, Hydroxytyrosol, Siberian Ginseng, Vitamins D3 & B Complex, Bio Aronia, Mursala Tea
These ingredients help restore clear cellular communication, support hormonal balance, and enhance coordinated organ function.
Chronic Inflammation (Inflammaging)
Chronic Inflammation (Inflammaging)
Low-grade, persistent inflammation becomes chronic with age. It causes damage to cells and tissues.
Nucleo Greens Ingredients
Vitamin C, Vitamin E, Quercetin, Resveratrol, Hydroxytyrosol, Zinc, Bio Aronia, Rose Hip Extract, Broccoli Extract, Mursala Tea
These ingredients activate anti-inflammatory pathways, to ensure that inflammation is only activated when needed.
Disabled Macroautophagy
Disabled Macroautophagy
Cells lose their ability to recycle and remove damaged components through autophagy.
Nucleo Greens Ingredients
Spermidine, Resveratrol, Quercetin, R-Alpha Lipoic Acid, Bio Spirulina, Green Phytonutrients
Together, these bioactives activate autophagy and mitophagy, the body's natural cellular cleanup and renewal systems.
They also trigger AMPK, the key longevity pathway that restores cellular energy balance, enhances repair, and supports long-term vitality.
Dysbiosis (Gut Imbalance)
Disabled Macroautophagy
The gut microbiome becomes imbalanced, beneficial bacteria decline while harmful ones overgrow. This weakens immunity, disrupts metabolism, and increases inflammation.
Nucleo Greens Ingredients
Probiotic Blend, GOFOS Prebiotic, L-Glutamine, Bio Banana Powder, Bio Aronia, Freeze-Dried Sour Cherry, Bio Spinach, Rose Hip Powder
These ingredients work together to restore microbial balance, strengthen gut lining integrity, and support immune resilience.
Genomic Instability
Genomic Instability
DNA damage accumulates daily from oxidative stress and accelerates aging.
Nucleo Greens Ingredients
Vitamin C, Vitamin E, Zinc, Hydroxytyrosol, Polyphenol-Rich Grape Extract, Bio Aronia, Bio Rose Hip Extract, Broccoli Extract, Resveratrol
These nutrients deliver powerful antioxidant defense and essential cofactor support for DNA repair enzymes
Telomere Attrition
Telomere Attrition
Telomeres shorten with each cell division. When they become too short, cells stop dividing and enter senescence, accelerating tissue aging.
Nucleo Greens Ingredients
Resveratrol, Quercetin, Hydroxytyrosol, Broccoli Extract, Spermidine, Siberian Ginseng, Bio Spirulina
These nutrients help activate key longevity pathways, including sirtuins, AMPK, and telomerase activity, supporting telomere stability and healthy cellular renewal.
Epigenetic Alterations
Epigenetic Alterations
The expression pattern of epigenetic markers changes with age, causing cellular dysfunction.
Nucleo Greens Ingredients
Broccoli Extract (Sulforaphane), Resveratrol, Quercetin, Spermidine, Vitamin B9 (5-MTHF), Vitamin B12, Inositol (B8)
These nutrients help preserve optimal gene regulation, maintain proper methylation balance, and promote youthful cellular expression patterns.
Loss of Proteostasis
Loss of Proteostasis
Damaged and misfolded proteins build up inside cells, causes damage to the cell.
Nucleo Greens Ingredients
Spermidine, Resveratrol, Quercetin, R-Alpha Lipoic Acid, Bio Spirulina, Mursala Tea Extract
These nutrients help enhance autophagy, reduce protein aggregation, and support the cell's natural protein repair systems for effective cellular maintenance.
Deregulated Nutrient Sensing
Deregulated Nutrient Sensing
Cellular nutrient and energy sensors (like mTOR, AMPK, and insulin signaling) become dysregulated. This leads to accelerated cellular aging.
Nucleo Greens Ingredients
Resveratrol, Quercetin, Siberian Ginseng, R-Alpha Lipoic Acid, Inositol (B8), Spermidine, CoQ10These compounds help activate key longevity pathways such as AMPK and sirtuins, supporting optimal metabolism, efficient energy use, and metabolic health.
Mitochondrial Dysfunction
Mitochondrial Dysfunction
Mitochondria, the cell's energy factories lose efficiency and produce more free radicals.This results in faster cellular deterioration.
Nucleo Greens Ingredients
CoQ10, R-Alpha Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Bio Spirulina, Bio Spinach, Hydroxytyrosol, Resveratrol
These nutrients help enhance mitochondrial energy output, optimize oxygen metabolism, and protect cells from oxidative damage
Cellular Senescence
Cellular Senescence
Aged or damaged cells stop dividing but release inflammatory molecules that damage surrounding healthy cells.
Nucleo Greens Ingredients
Quercetin, Resveratrol, Spermidine, Polyphenol-Rich Grape Extract, Hydroxytyrosol, Bio Aronia Extract
These compounds act as natural senolytics, helping to clear senescent cells, reduce inflammation, and restore healthy cellular function.
Stem Cell Exhaustion
Stem Cell Exhaustion
Stem cells lose their regenerative capacity.
Nucleo Greens Ingredients
Spermidine, Siberian Ginseng, Bio Spirulina, Hydroxytyrosol, Resveratrol, Vitamin D3, Zinc
These nutrients help support stem cell renewal, enhance tissue repair, and promote long-term cellular resilience.
Altered Intercellular Communication
Altered Intercellular Communication
Cells and organs stop communicating properly. This causes inflammation.
Nucleo Greens Ingredients
Resveratrol, Quercetin, Hydroxytyrosol, Siberian Ginseng, Vitamins D3 & B Complex, Bio Aronia, Mursala Tea
These ingredients help restore clear cellular communication, support hormonal balance, and enhance coordinated organ function.
Chronic Inflammation (Inflammaging)
Chronic Inflammation (Inflammaging)
Low-grade, persistent inflammation becomes chronic with age. It causes damage to cells and tissues.
Nucleo Greens Ingredients
Vitamin C, Vitamin E, Quercetin, Resveratrol, Hydroxytyrosol, Zinc, Bio Aronia, Rose Hip Extract, Broccoli Extract, Mursala Tea
These ingredients activate anti-inflammatory pathways, to ensure that inflammation is only activated when needed.
Disabled Macroautophagy
Disabled Macroautophagy
Cells lose their ability to recycle and remove damaged components through autophagy.
Nucleo Greens Ingredients
Spermidine, Resveratrol, Quercetin, R-Alpha Lipoic Acid, Bio Spirulina, Green Phytonutrients
Together, these bioactives activate autophagy and mitophagy, the body's natural cellular cleanup and renewal systems.
They also trigger AMPK, the key longevity pathway that restores cellular energy balance, enhances repair, and supports long-term vitality.
Dysbiosis (Gut Imbalance)
Disabled Macroautophagy
The gut microbiome becomes imbalanced, beneficial bacteria decline while harmful ones overgrow. This weakens immunity, disrupts metabolism, and increases inflammation.
Nucleo Greens Ingredients
Probiotic Blend, GOFOS Prebiotic, L-Glutamine, Bio Banana Powder, Bio Aronia, Freeze-Dried Sour Cherry, Bio Spinach, Rose Hip Powder
These ingredients work together to restore microbial balance, strengthen gut lining integrity, and support immune resilience.