Human cells can grow and divide only a limited number of times, around 50, before entering an irreversible state of growth arrest, known as cellular senescence.
When we are young, these senescent cells are efficiently cleared away by the immune system. However, once cells reach their natural limit, they begin releasing a mix of inflammatory molecules known as SASP (Senescence-Associated Secretory Phenotype).
Although inflammation is often seen as something negative, it can also serve an important purpose. Just as inflammation caused by an injury draws immune cells to aid healing, senescent cells “flag” themselves for removal by releasing inflammatory factors.
As we age, however, more senescent cells accumulate while our immune system becomes less efficient. What used to be a short, helpful burst of inflammation turns into a chronic, low-grade inflammation that drives ageing and many age-related diseases.
In studies, scientists have found that transplanting senescent cells from older mice into younger ones was enough to cause physical decline and even increase mortality by fivefold. Conversely, removing just a portion of these ageing cells dramatically slowed tumour growth and helped preserve organ function and age-related decline.
We can help our bodies keep senescent cells in check. Regular movement, a diet rich in plants, and ingredients with strong antioxidant and senolytic properties all play a role. Formulas like Nucleo Greens combine these powerful compounds to support natural cell repair and keep your body feeling energised, balanced, and resilient.